Table 1.

LTD₄ increases histamine-induced responses in capsaicin-sensitive nasal-specific neurones

	Histamine (10 μM)	LTD4 (500 nM)	Histamine+LTD4	P-value
Current clamp
Peak frequency (1 s bins)	9 (±4)	0.0	30 (±6)	0.005*
Action potentials	63 (±35)	0.0	157 (±40)	0.049*
Depolarization (mV)	14 (±3)	0.9 (±0.5)	33 (±7)	0.007*
Voltage clamp
Inward current (pA)	28 (±4.9)	8.3 (±8.3)	176 (±73)	0.042**
Current density (pA pF−1)	1.4 (±0.3)	0.4 (±0.4)	8.3 (±3.6)	0.041**

^*Significant increase in histamine responses in the presence of LTD₄ (histamine (n=8), LTD₄ alone and in combination with histamine (n=7)).

^**Significant increase in histamine-induced current in the presence of LTD₄ (n=7).