Table 1.
Morphometric and echocardiographic parameters
| Ctrl (9) | HF-1 (10) | HF-3 (14) | HF-Car 1 month (11) | HF-Car 3 months (11) | |
|---|---|---|---|---|---|
| Sudden death | 0 | 1 | 4 | 1 | 1 |
| (9) | (9) | (10) | (10) | ||
| Body weight (kg) | 4.2±0.18 | 4.0±0.06 | 4.2±0.10 | 4.2±0.06 | |
| Relative heart weight (g kg−1) | 2.5±0.08 | 4.7±0.13* | 5.5±0.39*† | 3.7±0.11*†‡ | |
| Relative lung weight (g kg−1) | 3.3±0.08 | 5.5±0.31* | 5.4±0.42* | 3.6±0.10†‡ | |
| Myocyte length (μm) | 147±1.9 | 186±2.4* | 188±3.5* | 163±2.8*†‡ | |
| Myocyte width (μm) | 25±0.3 | 29±0.6* | 32±0.8*† | 26±0.5†‡ | |
| Presence of ascites | 0 | 5* | 7* | 1†‡ | |
| LVEDP (mm Hg) | 4±0.5 | 17±2.6* | 26±3.1*† | 5±1.0†‡ | |
| (9) | (9) | (10) | (10) | (10) | |
| IVS dia (mm) | 2.5±0.08 | 3.2±0.17* | 3.5±0.15* | 3.3±0.18* | 2.8±0.09†‡ |
| IVS sys (mm) | 4.6±0.31 | 4.8±0.30 | 4.5±0.22 | 4.6±0.24 | 4.7±0.22 |
| LVWP dia (mm) | 2.8±0.11 | 3.9±0.14* | 4.0±0.21* | 3.7±0.16* | 3.1±0.11†‡ |
| LVWP sys (mm) | 3.9±0.15 | 4.4±0.16* | 4.4±0.17* | 4.2±0.22 | 4.0±0.20 |
| LV diameter dia (mm) | 15.4±0.34 | 20.8±0.54* | 23.4±0.73*† | 20.9±0.51*‡ | 17.7±0.17*†‡ |
| LV diameter sys (mm) | 8.3±0.44 | 14.2±0.59* | 18.2±0.86*† | 14.5±0.54*‡ | 10.3±0.23*†‡ |
| Fractional shortening (%) | 46±2.0 | 32±1.8* | 22±2.0*† | 30±1.8*‡ | 40±1.9*†‡ |
Abbreviations: dia, diastolic; sys, systolic; IVS, interventricular septum; LVEDP, left ventricular end diastolic pressure; LVWP, left ventricular wall posterior.
Mean±s.e.mean; P<0.05, *versus Ctrl, †versus HF-1, ‡versus HF-3; the number of rabbits is given in parentheses.