Figure 2.
ERCC1 complementation decreases L1 retrotransposition. The Chinese hamster ovary cell line (UV-20, ercc1) was characterized for it ability to support L1 retrotransposition. One day prior to transfection of the L1 construct, the cells were transfected with a hERCC1 expression construct or with the corresponding empty vector. (A) Sample plates of the L1 retrotransposition assay after serial transfection with control and hERCC1 expression vectors in ERCC1-deficient CHO-UV20 cells. (B) Quantitation of the relative effect of ERCC1 complementation on the L1 retrotransposition assay. (n = 4)