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. 2008 Jul 28;182(2):381–393. doi: 10.1083/jcb.200712066

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© 2008 Ghosh et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Gαi3 localizes preferentially in pseudopods at the leading edge. (A) Time-lapse images of a HeLa cell expressing Gαi3-YFP migrating into a freshly made wound visualized by live cell imaging. Gαi3-YFP is preferentially localized within pseudopods at the leading edge (carats) during polarized migration. Time after wounding is expressed as hours:minutes:seconds. Outline of the cell at the beginning of Video 2 (available at http://www.jcb.org/cgi/content/full/jcb.200712066/DC1) is indicated with a dashed line. (B) Similar images of a HeLa cell expressing mp-YFP. Mp-YFP shows a patchy distribution over most of the PM (arrows) and other membranous compartments with no preferential localization to the leading edge (carats). The dashed line indicates the position of the cell at the beginning of Video 3 (available at http://www.jcb.org/cgi/content/full/jcb.200712066/DC1).