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. 2008 Jul 28;182(2):301–313. doi: 10.1083/jcb.200712036

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© 2008 Cao et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — Model. In WT embryos, Nuf promotes actin polymerization at the invaginating furrow by properly localizing RhoGEF2 to the furrow, where it activates Rho1. Up-regulating actin polymerization stabilizes furrow membrane. In nuf mutant embryos, failed RhoGEF2 recruitment results in insufficient actin polymerization. This in turn results in loss of furrow membrane integrity.