Table 2.

Univariate Analysis in Derivation Sample

	Without Correction			Correction by MELD/Stage
	Odds ratio (95% CI)	p	c-statistic	Odds ratio (95% CI)	p
MELD	1.16(1.09-1.23)	<0.0001	0.763
Stage 3 or 4	2.33(1.25-4.33)	0.007	0.646
GGT	1.01(1.01-1.027)	<0.0001	0.913	1.011(1.01-1.02)	0.0006
MCV	1.62 (1.44-1.82)	<0.0001	0.902	1.61 (1.41-1.83)	<0.0001
AST/ALT	12.1 (5.7-25.7)	<0.0001	0.855	9.81(4.32-22.29)	<0.0001
Total Bilirubin	1.18(1.09-1.26)	<0.0001	0.846	1.07(0.98-1.18)	0.14
Alkaline Phosphatase	1.003 (1.001-1.004)	0.0003	0.833	1.001(1.000-1.003)	0.06
AST	1.006(1.003-1.010)	0.0007	0.794	1.004(0.999-1.008)	0.08
PTP1b	0.06(0.03-0.13)	<0.0001	0.791	0.08(0.04-0.19)	<0.0001
BMI	0.84(0.79-0.90)	<0.0001	0.735	0.79( 0.73.0.87)	<0.0001
Albumin	0.28(0.16-0.47)	<0.0001	0.723	0.52 (0.28-1.00)	0.05
Triglyceride	0.993(0.988-0.998)	0.005	0.669	0.996(0.990-1.001)	0.10
Sex (M=1)	3.35 (1.72-6.50)	0.0004	0.660	4.37(1.96-9.76)	0.0003
Grade (2 vs 1)	2.48 (1.24-4.96)	0.01	0.65	2.68(1.21-5.89)	0.01
Grade (3 vs 2)	6.66 (1.88-23.54)	0.003	0.65	3.63(0.78-16.81)	0.01
INR	3.07 (1.29-7.29)	0.01	0.634	0.35(0.13-0.94)	0.04
DM	0.48 (0.23-0.99)	0.048	0.572	0.32(0.13-0.79)	0.01
Fasting Glucose	0.99(0.98-1.02)	0.14	0.551	0.99(0.983-0.999)	0.03
Age	1.01(0.99-1.04)	0.40	0.541	0.99(0.96-1.02)	0.55
ALT	0.998(0.995-1.002)	0.34	0.539	0.998( 0.995-1.001)	0.27

Variables are listed in descending order of c-statistic prior to correction by MELD and Stage. The variables remaining significant (p≤0.01) after correction for MELD and fibrosis stage are bolded.