Table 1.

Studies of amygdala volumetry in bipolar disorder.

Study	Sample size (% Male)	Bilateral amyg volume (cm3)	Age	Results	Imaging techniques
Swayze et al., 1992	48 BP (60% M)	2.19.±0.66 BP	34.02 BP	No significant difference	0.5 T
	47 C (60% M)	2.05±0.66 C			1-cm coronal
Pearlson et al., 1997	27 BP (59% M)	1.26±0.21 BP	34.9±8.6 BP	L amyg smaller	1.5 T
	60 C (72% M)	1.37±0.19 C	31.6±8.0 C		3-mm coronal
Altshuler et al., 1998	12 BP (100% M)	1.94±0.36 BP	50.8±13.3 BP	Overall amyg larger	1.5 T
	18 C (100% M)	1.69±0.36 C	53.4±11.1 C		1.4-mm coronal
Strakowski et al., 1999	24 BP (71% M)	3.55±0.55 BP	27±6 BP	R and L amyg larger	1.5 T
	22 C (59% M)	3.15±0.4 C	28±6 C		1-mm coronal
Altshuler et al., 2000	24 BP (100% M)	1.91±0.35 BP	50.2±12.7 BP	Overall amyg larger	1.5 T
	18 C (100% M)	1.69±0.36 C	53.4±11.1 C		3D 1.4 mm coronal
Blumberg et al., 2003	36 BP (44% M)			Overall amyg smaller
	(14 adolescent)	1.80±0.05 BP	31.0±14.1 BP		1.5 T
	56 C (52% M)	2.14±0.04 C	28.3±13.7 C		3D 1.2 mm sagittal
	(23 adolescent)
Brambilla et al., 2003	24 BP (63% M)	2.57±0.69 BP	35±10 BP	L amyg larger	1.5T
	36 C (61% M)	2.17±0.58 C	37±10 C		3D 1.5 mm coronal
DelBello et al., 2004	23 BP (61% M)			Overall amyg smaller
		2.5±0.4 BP	16.3±2.4 BP		1.5 T
	20 C (55% M)
		2.75±0.3 C	17.2±1.9 C		3D 1 mm axial
	Adolescent
Chen et al., 2004	16 BP (50% M)			Age dependent reduction of R amyg
		1.86±0.41 BP	16±3 BP		1.5 T
	21 C (57% M)
		1.99±0.50 C	17±4 C		3D 1.5 mm coronal
	Adolescent
Frazier et al., 2005	43 BP (54% M)			No significant difference
		1.67±0.26 BP	11.3±2.7 BP		1.5 T
	20 C (60% M)
		1.80±0.30 C	11.0±2.6 C		3D 1.5 mm coronal
	Adolescent
Chang et al., 2005	20 BP (80% M)			Overall amyg smaller
		3.93±0.40 BP	14.6±2.8 BP		3 T
	20 C (80% M)
		4.39±0.45 C	14.1±2.8 C		3D 1.5 mm coronal
	Adolescent

Note: Amyg = amygdala, BP = bipolar disorder, C = control, L = left hemisphere, R = right hemisphere, M = male.