Figure 7. Roles of MAVS in the interaction of CS and poly(I:C).

WT (+/+) mice and mice with null mutations (–/–) of MAVS were exposed to CS or RA (CS–) for 2 weeks and then given 4 doses of poly(I:C) (50 μg) or vehicle control. BAL total cell recovery (A), IFN-γ production (B), and alveolar remodeling (C) were evaluated. The noted values represent the mean ± SEM of evaluations in a minimum of 5 mice. *P < 0.05; **P < 0.01.