Table 2.

Candidate genes for ARVD [37]

Components of the desmosome
Desmosomal cadherins (desmocollins; desmogleins)*
Desmoplakin*
Emerin
Plectin
Plakophilin*
Tyrosine kinases that phosphorylate desmosomal proteins
Components of the adherens junction
α-catenin
β-catenin
γ-catenin (junctional plakoglobin)*
N-cadherin
Constituents of the gap junction
Connexin 43
Others
Cardiac ryanodine receptor*
Components of dystrophic-glycoprotein complex
Desmin
Laminin receptor-1
Myotonic dystrophy protein kinase-1
Transforming growth factor β3*

*genes that have been definitively implicated in ARVD.

Of the other genes listed above, many are currently under investigation for a potential etiological role in ARVD