Table 2.

Disease mutation distribution by channel region

Region	HERG	KCNQ1
N-term	6%	2%
PAS	21%	NA
VSD	9%	11%
ICL	3%	20%
ECL	23%	6%
Pore	23%	29%
C-term	15%	32%

PAS = Per-Arnt-Sim domain in HERG, N-term = N-terminal region used in analysis (excluding PAS domain in HERG), ECL = extracellular linker regions between S1–S2, S3–S4, S5-P loop and P-loop-S6, ICL = intracellular linker regions between S2–S3 and S4–S5, VSD = voltage sensing domain (only transmembrane portions), Pore = pore region including S5, P-loop and S6, C-term = C-terminal portion of channels used in this analysis.