FIGURE 1.

Schematic diagram of AD. Rigid, cylindrical microvilli are randomly placed on the surface of a sphere. Adhesion molecules are assigned randomly to these microvilli according to a Poisson distribution, and the wall is assumed to be a uniformly reactive planar surface. Length-dependent binding probabilities govern the formation and breakage of bonds. Resting integrins are stochastically activated within a MV-level KMC module. Translational and rotational velocity are calculated from forces and torques due to bonds, gravity, nonspecific surface repulsion, and hydrodynamic flow using a mobility matrix. G = shear rate.