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. 2008 May 16;95(4):1795–1812. doi: 10.1529/biophysj.108.130195

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IP3 concentration in constructed 3D geometry for central spine stimulated 12 times in succession beginning at t = 0.1 s. IP3 concentration results from cleavage of PIP2, which is rapidly depleted. Each excitation follows the last by = 0.012 s. (Inset) Corresponding PIP2 concentration at central spine in constructed 3D geometry. The results show that calculated basal levels of PIP2 in the Purkinje neuron spine membrane (4000 mol/μm²) are not sufficient to produce large amounts of IP3.

Inline graphic — IP3 concentration in constructed 3D geometry for central spine stimulated 12 times in succession beginning at t = 0.1 s. IP3 concentration results from cleavage of PIP2, which is rapidly depleted. Each excitation follows the last by = 0.012 s. (Inset) Corresponding PIP2 concentration at central spine in constructed 3D geometry. The results show that calculated basal levels of PIP2 in the Purkinje neuron spine membrane (4000 mol/μm²) are not sufficient to produce large amounts of IP3.