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. 2008 May 16;95(4):1795–1812. doi: 10.1529/biophysj.108.130195

FIGURE 7.

FIGURE 7

(a) Virtual Cell Reaction scheme for activation of PLC, cleavage of bound and unbound PIP2, and local sequestration of PIP2 by a binding protein or “sink”. The gray circle encloses the section of the reaction scheme representing local sequestration. PLC is allowed to cleave free PIP2 as well as PIP2 bound to the “sink” protein or complex. Other details are similar to Fig. 6 a. (b) IP3 concentration for central spine stimulated 12 times at 80 Hz beginning at t = 0.1 s, with local sequestration of PIP2 added to the model using the constructed 3D geometry. The IP3 concentration results from cleavage of both free PIP2 and PIP2 bound to a binding protein or “sink”.