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. 2008 May 9;95(4):2037–2048. doi: 10.1529/biophysj.107.128249

FIGURE 1.

FIGURE 1

Simultaneous measurement of [Ca] changes during spontaneous Ca waves in the cytosolic and SR luminal compartments, using the Ca indicators Rhod-2 and Fluo-5N. Representative images of Ca waves and intra-SR [Ca] recorded in permeabilized dog ventricular myocytes overexpressing WT or mutant forms of CASQ2 (48 h after adenoviral infection). Traces represent time-dependent profiles of cytosolic Rhod-2 and luminal Fluo-5N signals. Spontaneous Ca waves were induced by lowering [EGTA] from 200 μM to 50 μM (PCa7) in the internal solution.