FIGURE 3.

Three-dimensional model of diffusion in brain ECS. (A) Schematic of three-dimensional model of diffusion in brain ECS showing a cubic lattice arrangement of cells containing lakes at multicell contact points (left). ECS geometry with narrow gaps and lake regions (right). (B) Representative MSD plots. Parameters α ∼ 21.5%, d_cell = 10 μm, and indicated g_c. (C) D_o/D as a function of (left) α, (middle) g_c, and (right) d_cell. Parameters: (left) d_cell = 10 μm, g_c = 80 nm; (middle) α ∼ 21.5%, d_cell = 10 μm; (right) α ∼ 21.5%, g_c = 80 nm.