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. 2008 May 9;95(4):1785–1794. doi: 10.1529/biophysj.108.131466

FIGURE 5.

FIGURE 5

Characteristics of the modified lake model of 3D diffusion in brain ECS. (A) Do/D as a function of α. Two types of modifications were made to change α—altered wc (open circles) and fixed wc (altered lake mass, solid circles). Parameters: gc = 80 nm, dcell = 10 μm. (B) Do/D as a function of gc. Parameters: α = 21.8–22.6%, dcell = 10 μm. (C) Do/D as a function of dsolute. Parameters: gc = 100 nm, α = 21.9%, dcell = 5 μm. (D) Effect of heterogeneity in gc. Do/D shown for zero solute size (solid bars) and 60 nm solute size (open bars). Parameters: α = 21.9%, dcell = 5 μm.