FIGURE 6.

Model comparisons with experimental data for solute size-dependent diffusion in mouse brain ECS. (A) Representative fluorescence recovery curves of indicated fluorescent dyes in cerebral cortex (left) and caudate nucleus (right). (B) Summary showing D_o/D for ECS diffusion as a function of solute size (d_solute) in cerebral cortex (triangles) and caudate nucleus (circles) (SE, n = 5). Experimental data (solid) and simulated results (open) are overlaid. Simulation parameters: (g_c^x, g_c^y, g_c^z) = (40, 40, 40) nm for cerebral cortex, (g_c^x, g_c^y, g_c^z) = (10, 25, 45) nm for caudate nucleus, α ∼ 20%, d_cell = 5 μm, w_c = 90 nm.