Fig 3 Prediction of adjuvant therapy benefit. The web based program Adjuvant! Online (www.adjuvantonline.com) estimates the benefit of adjuvant therapy. Graphically displayed are the benefits of adjuvant therapy for a woman with a 10 year breast cancer specific mortality of 30%, that can be reduced by 8% with hormonal therapy and a further 9% with chemotherapy. For every 100 similar women treated with chemotherapy, 91 might receive chemotherapy unnecessarily, although 9 will be cured. Adapted with permission from Adjuvant! Online version 8 (www.adjuvantonline.com).