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. 2008 Aug 8;4(8):e1000122. doi: 10.1371/journal.ppat.1000122

Figure 4. The role of IgM in VSG-specific protection.

Figure 4

(A) BALB/c WT (□), IgM−/− (▴) and µMT (▪) mice were infected with 5000 pleomorphic AnTat 1.1E parasites. (B) BALB/c WT mice were infected with 5000 monomorphic AnTat 1.1 (•) or MITat 1.4 (▒) parasites. (C) AnTat 1.1E infected BALB/c WT (□) mice were super-infected (S.I.) on day 6 or (D) on day 10 with 5000 parasites of a homologous, monomorphic AnTat 1.1 (•) or a non-homologous monomorphic, MITat 1.4 (▒) strain. (E) AnTat 1.1E infected BALB/c µMT (□) and (F) BALB/c IgM−/− (□) mice were super-infected with AnTat 1.1 (•) or MITat 1.4 (▒) parasites using the same strategy described above in C–D. (G) BALB/c WT (□) and BALB/c nu/nu (▾) mice were infected with 5000 AnTat 1.1E parasites and (H) were super-infected AnTat 1.1 (•) or MITat 1.4 (▒) parasites using the same strategy described above in C–D. All primary and super-infections were done by intra-peritoneal inoculation of 5000 parasites. Mortality was recorded using 10 mice per experimental group and the results were compared to mice that only received the primary infection. One out of 3 representative experiments is shown.