Table 5.
Synergistic effect of AGT235 MM and AT1R CC genotypes and classical risk factors in CAD patients and controls
| Classical risk factor | AGT235 MM | Whole population1 | AT1R CC | Whole population1 | ||||
| Hypertension | CAD | Controls | OR(95%CI) | CAD | Controls | OR(95%CI) | ||
| 0 | 0 | 88 | 293 | 1 | 0 | 99 | 334 | 1 |
| 0 | 1 | 18 | 62 | 0.97(0.52–1.78)NS | 1 | 7 | 21 | 1.12(0.42–2.89)NS |
| 1 | 0 | 153 | 130 | 3.92(2.77–5.55)*** | 0 | 182 | 150 | 4.09(2.96–5.66)*** |
| 1 | 1 | 39 | 25 | 5.19(2.88–9.41)*** | 1 | 10 | 5 | 6.75(2.06–23.27)** |
| SI = 1.44; SIM = 1.36; RERI = 1.30; AP = 0.25 | SI = 1.79; SIM = 1.47; RERI = 2.54; AP = 0.38 | |||||||
| Smoking | ||||||||
| 0 | 0 | 145 | 315 | 1 | 0 | 177 | 356 | 1 |
| 0 | 1 | 37 | 58 | 1.39(0.86–2.24)NS | 1 | 5 | 17 | 0.59(0.19–1.74)NS |
| 1 | 0 | 96 | 108 | 1.93(1.36–2.75)** | 0 | 104 | 128 | 1.63(1.18–2.27)** |
| 1 | 1 | 20 | 29 | 1.50(0.79–2.85)NS | 1 | 12 | 9 | 2.68(1.03–7.05)* |
| SI = 0.38; SIM = 0.56; RERI = -0.82; AP = -0.55 | SI = 7.64; SIM = 2.79; RERI = 1.46; AP = 0.54 | |||||||
| Obesity | ||||||||
| 0 | 0 | 172 | 352 | 1 | 0 | 201 | 394 | 1 |
| 0 | 1 | 42 | 65 | 1.32(0.84–2.07)NS | 1 | 13 | 23 | 1.11(0.52–2.34)NS |
| 1 | 0 | 69 | 71 | 1.99(1.34–2.95)** | 0 | 80 | 90 | 1.74(1.22–2.50)** |
| 1 | 1 | 15 | 22 | 1.40(0.67–2.89)NS | 1 | 4 | 3 | 2.61(0.49–14.83)NS |
| SI = 0.31; SIM = 0.53; RERI = -0.91; AP = -0.65 | SI = 1.89; SIM = 1.35; RERI = 0.76; AP = 0.29 | |||||||
| Diabetes | ||||||||
| 0 | 0 | 171 | 396 | 1 | 0 | 201 | 450 | 1 |
| 0 | 1 | 41 | 80 | 1.19(0.77–1.84)NS | 1 | 11 | 26 | 0.95(0.43–2.05)NS |
| 1 | 0 | 70 | 27 | 6.00(3.63–9.98)*** | 0 | 80 | 34 | 5.27(3.34–8.33)*** |
| 1 | 1 | 16 | 7 | 5.29(2.00–14.47)*** | 1 | 6 | 0 | -- |
| SI = 0.83; SIM = 0.74; RERI = -0.90; AP = -0.17 | -- | |||||||
| Dyslipidaemia | ||||||||
| 0 | 0 | 73 | 370 | 1 | 0 | 82 | 424 | 1 |
| 0 | 1 | 14 | 80 | 0.89(0.45–1.71)NS | 1 | 5 | 26 | 0.99(0.32–2.83)NS |
| 1 | 0 | 168 | 53 | 16.07(10.59–24.43)*** | 0 | 199 | 60 | 17.15(11.62–25.37)*** |
| 1 | 1 | 43 | 7 | 31.14(12.81–79.15)*** | 1 | 12 | 0 | -- |
| SI = 2.01; SIM = 2.18; RERI = 15.18; AP = 0.49 | -- | |||||||
SI, Rothman's synergy index for interaction; RERI, relative excess risk due to interaction; AP, proportion of disease attributable to interaction; *P < 0.05, **P < 0.005, ***P < 0.0001; 1We performed no further subdivision when analysing these polymorphisms because several classes resulted statistically impossible to analyse due to the reduced number of individuals there included.