Table 1.
Demographic details, treatment outcomes based on virologic responses, viral load at baseline and serial serum samples analysed over time for HCV genotype 3a chronically infected patients
| Patient Group | Type of Response | Sex | Rx Naïve | Age (years) at Baseline | Viral Load log10 IU/ml at Baseline | Time points | ||||||
| Pre treatment period | Early treatment period | Post treatment period | ||||||||||
| Sustained virological response (SVR) | Mean Age 41 ± 12 | Mean VL 5.66 ± 0.66 | E | B | W1 | W2 | W3 | W4 | L | |||
| SVR3 | SVR | F | Yes | 28 | 5.47 | + | + | + | + | + | - (V) | TND |
| SVR6 | SVR | F | Yes | 35 | 5.16 | + | + | - (V) | TND | TND | TND | TND |
| SVR7 | SVR | F | Yes | 32 | 5.46 | + | + | + | - (V) | TND | TND | TND |
| SVR8 | SVR | F | Yes | 59 | 6.89 | + | + | + | NA | NA | + (V) | TND |
| SVR9 | SVR | F | No | 45 | 6.37 | + | + | + | + | NA | - (V) | TND |
| SVR12 | SFR | F | Yes | 49 | 5.17 | + | + | TND | TND | TND | TND | TND |
| Treatment failure (TF) | Mean Age 41 ± 7 | Mean VL 6.23 ± 0.63 | E | B | W1 | W2 | W4 | W12* | L | |||
| NR2 | NR | F | Yes | 42 | 5.05 | + | + | + | NA | + | + | + (W3) |
| R1 | R | M | Yes | 46 | 7.5 | + | + | + (V) | TND | TND | TND | + (W2) |
| R4 | R | M | Yes | 45 | 7.11 | + | + | + | + (V) | TND | TND | + (W10) |
| R13 | R | M | Yes | 31 | 6.32 | + | + | + | - | TND | TND | - (W12) |
The pre treatment period corresponds to E and B time point. E for early sample, taken between 6 to 12 months before treatment and B for baseline sample, taken at day 0 of pegylated INF-α2a/ribavirin treatment. The early treatment period corresponds to W1 to W4 time points (samples taken at 1, 2, 3 or 4 weeks of treatment). The sample taken at week 12 of treatment was only available for the non-responder patient (W12*). The post treatment period corresponds to the L time point and was only available within the TF group. L for late sample taken at 2, 3, 10 or 12 weeks after the end of treatment). +, sample available with successful analysis. -, sample available with unsuccessful analysis. TND, target not detected when HCV RNA was not detectable in the sample. (V), sample treated with the Viraffinity™ reagent. NA, sample non available for analysis.