Table 1.
Group sham | Group shock-40 | Group shock-30 | |
AST (Mean ± SD, U/L) | |||
Baseline | 18.0 ± 1.9 | 25.0 ± 9.7a | 21.7 ± 9.3c, e |
End of shock | 20.4 ± 2.2 | 25.4 ± 8.9a | 29.3 ± 7.2c, e |
30 min | 20.8 ± 3.1 | 29.0 ± 8.4a | 37.0 ± 5.0c, e |
60 min | 24.0 ± 1.6 | 32.6 ± 9.1a | 44.0 ± 2.6c, f |
90 min | 23.4 ± 3.2 | 39.0 ± 13.9b | 54.7 ± 6.0d, e |
120 min | 24.6 ± 2.7 | 45.8 ± 15.4b | 61.0 ± 6.6d, f |
ALT (Mean ± SD, U/L) | |||
Baseline | 17.6 ± 3.2 | 20.2 ± 7.4a | 17.7 ± 4.2c, e |
End of shock | 19.6 ± 3.6 | 23.4 ± 7.5a | 20.3 ± 8.5c, e |
30 min | 18.4 ± 2.5 | 25.0 ± 7.2a | 23.0 ± 8.5c, e |
60 min | 18.8 ± 2.6 | 28.4 ± 8.3a | 24.3 ± 8.1c, e |
90 min | 18.2 ± 1.6 | 31.0 ± 8.9a | 24.6 ± 8.1c, e |
120 min | 19.4 ± 1.5 | 34.4 ± 8.5b | 31.7 ± 8.1c, e |
Creatinine (Mean ± SD, mg/dl) | |||
Baseline | 1.10 ± 0.42 | 0.90 ± 0.07a | 1.10 ± 0.20c, e |
End of shock | 1.08 ± 0.38 | 0.96 ± 0.15a | 1.33 ± 0.32c, e |
30 min | 1.04 ± 0.34 | 1.02 ± 0.08a | 1.27 ± 0.40c, e |
60 min | 0.94 ± 0.21 | 1.08 ± 0.13a | 1.37 ± 0.35c, e |
90 min | 0.88 ± 0.28 | 1.08 ± 0.22a | 1.50 ± 0.36d, e |
120 min | 0.90 ± 0.29 | 1.22 ± 0.32a | 1.63 ± 0.46d, f |
Serum concentrations of aspartate aminotransferase (AST), alanine aminotransferase (AST) and creatinine of animals undergoing sham operation (group sham); animals undergoing hemorrhagic shock to MAP 40 mmHg (group shock-40) before start of resuscitation; and animals undergoing hemorrhagic shock to MAP 30 mmHg (group shock-30) before start of resuscitation.
Statistical comparisons after Bonferroni correction
Group sham vs group shock-40: apNS (non-significant); bp < 0.05
Group sham vs group shock-30: cpNS (non-significant); dp < 0.05
Group shock-40 vs group shock-30: epNS (non-significant); fp < 0.05