. Author manuscript; available in PMC: 2008 Sep 1.

Published in final edited form as: Nat Rev Cancer. 2008 Mar;8(3):212–226. doi: 10.1038/nrc2345

Table 1.

SIBLING expression in normal and malignant human tissues as well as correlation with disease progression

Organ/tissue	OPN			BSP			DMP1			DSPP
	normal^*	Tumour^‡	Prog’n^§	normal	Tumour	Prog’n	normal	Tumour	Prog’n	normal	Tumour	Prog’n
Bladder	Low¹⁶⁴	High¹⁷⁹	Yes¹⁸⁰	ND	High¹⁵⁸	ND	ND	ND	ND	ND	ND	ND
Bone	High¹⁶⁴	High¹⁸¹	No¹⁸¹	High¹⁸²	High¹⁸³	Yes¹⁸³	High¹⁸⁴	ND	ND	Low¹⁸⁵	ND	ND
Brain	Low¹⁷⁹	High¹⁸⁶	Yes¹⁸⁶	ND	ND	ND	ND	ND	ND	ND	ND	ND
Breast	Low¹⁶⁴	High¹⁸⁷	Yes¹⁸⁸	Low⁶⁴	High⁶⁴	Yes¹³⁵	Low¹²¹	High¹²¹	Yes¹²¹	ND	ND	ND
Cervix	Low¹⁶⁴	High¹⁸⁹	Yes¹²⁷	Low¹¹⁶	High¹¹⁶	Yes¹¹⁶	ND	ND	ND	ND	ND	ND
Colon	Low¹⁶⁴	High¹⁰⁷	Yes¹⁹⁰	Low⁵⁴	High⁵⁴	ND	Low⁵⁴	High⁵⁴	ND	Low⁵⁴	Low⁵⁴	ND
Connective tissue	No¹⁶⁴	High¹⁹¹	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
Gastric	No¹⁶⁴	High¹⁹²	Yes¹⁴³	ND	ND	ND	ND	ND	ND	ND	ND	ND
Oral mucosa	No¹¹⁹	High¹¹⁹	Yes¹¹⁹	No¹¹⁹	High¹¹⁹	No¹¹⁹	No¹¹⁹	No¹¹⁹	No¹¹⁹	No¹¹⁹	High¹¹⁹	Yes¹¹⁹
Kidney	High¹⁵,¹⁶⁴	High¹⁹³	Yes¹²⁶	High¹⁵	ND	ND	High¹⁵	ND	ND	High¹⁵	ND	ND
Bone marrow	No¹⁹⁴	High¹⁹⁵	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
Lung	No¹⁶⁴	High¹⁹⁶	Yes¹³³	Low⁵⁴	High⁶⁶	Yes¹³⁶	Low⁵⁴,¹²⁰	High⁵⁴,¹²⁰	ND	Low⁵⁴	High⁵⁴	ND
Lymphocytes	Low¹⁹⁷	High¹⁰⁶	Yes¹⁹⁸	ND	High⁶⁷	ND	ND	ND	ND	ND	ND	ND
Melanocytes	No¹⁹⁹	High²⁰⁰	Yes²⁰⁰	ND	High¹¹⁸	ND	ND	ND	ND	ND	ND	ND
Oesophagus	ND	High¹⁷⁹	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
Ovary	No¹⁶⁴	High²⁰¹	Yes¹²⁵	Low⁵⁴	Low⁶⁶	ND	ND	ND	ND	ND	ND	ND
Pancreas	No¹⁶⁴	High¹⁴⁶	Yes⁴⁵	Low¹¹⁷	High¹¹⁷	ND	ND	ND	ND	ND	ND	ND
Prostate	No¹⁶⁴	High²⁰²	Yes²⁰³	No⁵⁴	High⁶⁵	Yes⁶⁵	No⁵⁴	ND	ND	Low²	High²	Yes²
Rectum	ND	High²⁰⁴	Yes²⁰⁴	ND	ND	ND	ND	ND	ND	ND	ND	ND
Thyroid	No¹⁷⁹	High¹³²	ND	No¹¹⁵	High¹¹⁵	ND	Low⁵⁴	High⁵⁴	ND	ND	ND	ND

Defines expression of the designated small integrin-binding ligand N-linked glycoprotein (SIBLING) at the protein or mRNA level in normal tissue.

^‡

Defines expression of the designated SIBLING at the protein or mRNA level in primary malignant lesions.

^§

Defines a positive and significant association between the level of expression of the designated SIBLING in the primary malignant lesions and the subsequent development of distant metastases and/or poor disease survival.

Note that the association was negative for dentin matrix acidic phosphoprotein 1 (DMP1) expression in breast cancer and disease progression.

BSP, bone sialoprotein; DSPP, dentin sialophosphoprotein; ND, not determined; OPN, osteopontin; Prog’n, progression.