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. 1971 Feb;105(2):556–564. doi: 10.1128/jb.105.2.556-564.1971

Effects of N-Hydroxyurethan on Viability and Metabolism of Escherichia coli

Kathleen P Mullinix a,1, Herbert S Rosenkranz a
PMCID: PMC248421  PMID: 5107618

Abstract

Exposure of growing cells to low levels of N-hydroxyurethan (approximately 0.05 m) resulted in loss of colony-forming ability. This was accompanied by degradation of cellular deoxyribonucleic acid. When the concentration of N-hydroxyurethan was increased to 0.2 m, bacteriostasis was the primary manifestation. The lethal action of the drug was prevented by contreatment with chloramphenicol or azauracil or by uracil-deprivation of a bacterial strain requiring this pyrimidine for growth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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