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. 1989 Apr;63(4):1808–1810. doi: 10.1128/jvi.63.4.1808-1810.1989

Immunization against multiple viruses by using solid-matrix-antibody-antigen complexes.

R E Randall 1, D F Young 1
PMCID: PMC248452  PMID: 2538658

Abstract

We have previously shown that mice immunized with solid-matrix-antibody-antigen (SMAA) complexes in the absence of adjuvants show vigorous humoral and cell-mediated immune responses to the immunizing antigen. Here we report that various proteins involved in inducing protective immune responses to different viruses can easily and simply be incorporated into SMAA complexes and that such complexes act as powerful multivalent immunogens. Construction of such SMAA complexes may be one of the most practical and effective ways of producing multivalent subunit vaccines for use in humans and animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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