Fig. 8.
One hundred µM 5-methylfurmethiodide (MFI) increases the threshold for activation of voltage-activated calcium currents. A) Control currents (left) activated by step potentials from a holding potential of −35 mV. Currents in the presence of 100 µM MFI (middle) and following washout (right). B) Plot of the peak inward calcium current at different step potentials. Control (●), 100 µM MFI (Δ), wash (□). Note that it takes a greater depolarization step to activate the current. C) Bar chart of the peak calcium current at −5 mV in the control, presence of 100 µM MFI and following washout. MFI had a significant (P < 0.05 paired t-test n = 4) effect compared with control and wash.