Table 2.

Cerebrospinal fluid and plasma diclofenac concentrations in each patient after i.v. injection of 1 mg kg⁻¹ (n = 31)

Sampling time (h and min)	CSF concentration (μg l−1)	Unbound plasma concentration (μg l−1)	Total plasma concentration (μg l−1)	Ratio CSF/unbound plasma concentration	Age (years and months)	Height (cm)	Weight (kg)
5 min	0.7	1.2	2073	0.60	6 years 11 months	120	22
6 min	0.6	1.0	1005	0.66	4 years 3 months	113	21
10 min	3.6	1.6	1914	2.3	3 months	60	7
10 min	0.9	2.0	4232	0.46	7 years 6 months	111	19
11 min	0.8	1.9	2157	0.42	2 years 11 months	96	14
14 min	0.8	3.8	1618	0.20	4 years 8 months	111	24
17 min	0.5	0.9	1308	0.58	6 years 2 months	120	23
20 min	1.2	1.2	2024	1.0	2 years 2 months	90	14
20 min	1.2	1.2	2213	0.95	12 years 5 months	169	60
24 min	2.4	1.0	1442	2.3	1 year 5 months	83	11
30 min	1.7	0.8	718	2.3	3 years 11 months	107	21
43 min	3.1	0.6	666	5.2	1 year 5 months	80	11
44 min	2.2	0.7	540	3.0	6 years 4 months	116	22
51 min	1.6	0.8	359	2.2	12 years 9 months	141	34
60 min	4.7	0.9	753	5.1	5 months	62	6
1 h 9 min	1.4	0.6	276	2.4	7 years 11 months	131	32
1 h 23 min	1.4	0.4	138	3.4	2 years 6 months	85	11
1 h 28 min	1.7	0.8	253	2.1	10 years 1 month	143	31
1 h 54 min	1.4	0.4	591	3.7	4 years 11 months	114	20
2 h 2 min	1.3	ND	111		5 years 7 months	118	22
2 h 4 min	1.1	ND	148		6 years	130	29
2 h 19 min	1.1	ND	113		1 year 4 months	75	11
2 h 25 min	0.9	0.4	116	2.3	9 months	76	11
2 h 28 min	0.9	0.5	77	1.9	7 years 10 months	122	25
2 h 50 min	3.2	ND	66		10 months	75	10
3 h 10 min	0.7	ND	55		3 years 5 months	97	14
3 h 11 min	1.0	0.4	91	2.4	10 years 8 months	140	41
3 h 43 min	0.6	ND	80		6 years	122	31
5 h 33 min	0.1	14.8	57	0.008	11 years 1 month	136	32
21 h 56 min	ND	ND	ND		9 months	68	8
22 h	ND	ND	ND		3 months	67	9

ND, not detected.