Table 1.

Effect of CYP3A5 polymorphism on tacrolimus pharmacokinetics in healthy Japanese

CYP3A5	n (M/F)	Age (years)	Weight (kg)	AUC0−8h (ng h ml−1)	CL/F (l h−1 kg−1)
*1 carrier	14 (13/1)	35.6 ± 8.0	66.2 ± 11.0	26.8 ± 9.5 (21.8, 31.7)	1.33 ± 0.61 (1.01, 1.64)
*3/*3	6 (5/1)	26.2 ± 1.3	66.2 ± 11.8	48.0 ± 21.9 (30.5, 65.6)	0.73 ± 0.25 (0.53, 0.93)
P-value†	–	0.009	–	0.032	0.032

^†Mann–Whitney U-test. Values are given as number of subjects or mean ± SD. Values in parentheses represent the 95% confidence interval.