Figure 3.

Mean (95% CI) plasma glucagon (A), adrenaline (B) and noradrenaline (C) concentrations following the administration of an intravenous infusion of insulin in six fasting male patients with type 1 diabetes studied on two separate occasions. Patients received a suppository of 100 mg indomethacin alone or 100 mg indomethacin and 1 mg glucagon at the hypoglycaemic reaction (↓). Glucagon concentrations rose significantly after the glucagon suppository was inserted and remained elevated for 90 min but did not change after placebo. Peak catecholamine responses to hypoglycaemia were no different on the two study days