Table 1.
Mean ± SD concentrations of growth hormone, cortisol and intermediary metabolites in six patients with type 1 diabetes taken at baseline, and peak/nadir response after induced hypoglycaemia with the addition of rectal glucagon (1 mg) or placebo at the hypoglycaemic reaction. There were no significant differences in the concentration of all parameters at any time point between groups, nor in the timing of the peak/nadir response to hypoglycaemia
| Basal | Peak/Nadir | ||
|---|---|---|---|
| Growth hormone (mU l−1) | Placebo | 7.2 ± 3.6 | 59.3 ± 6.1 |
| Glucagon | 5.8 ± 3 | 60.5 ± 3.1 | |
| Cortisol (nmol l−1) | Placebo | 528.8 ± 63.4 | 744.2 ± 48.5 |
| Glucagon | 486.5 ± 65 | 690 ± 18.1 | |
| Lactate (nmol l−1) | Placebo | 1.38 ± 0.07 | 2.18 ± 0.31 |
| Glucagon | 1.37 ± 0.12 | 2.12 ± 0.12 | |
| Acetoacetate (nmol l−1) | Placebo | 0.89 ± 0.28 | 0.26 ± 0.07 |
| Glucagon | 1.27 ± 0.38 | 0.18 ± 0.05 | |
| Glycerol (μmol l−1) | Placebo | 10.4 ± 2 | 14.6 ± 2.8 |
| Glucagon | 10.8 ± 2.1 | 18.4 ± 2.9 | |
| Free fatty acids (nmol l−1) | Placebo | 0.63 ± 0.17 | 0.47 ± 0.14 |
| Glucagon | 0.68 ± 0.24 | 0.32 ± 0.09 |