Table 2.
Effect of anticoagulants and antidepressants drugs on the rate of gastrointestinal haemorrhage
| Agent | Cases (n = 4028) | Controls (n = 40 171) | Crude rate ratio | Adjusted rate ratio * | 95% confidence interval |
|---|---|---|---|---|---|
| Antidepressants | |||||
| SSRI | 335 (8.3%) | 1780 (4.4%) | 1.97 | 1.33 | 1.09, 1.62 |
| TCA | 262 (6.5%) | 1764 (4.4%) | 1.52 | 1.04 | 0.83, 1.30 |
| Venlafaxine | 56 (1.4%) | 229 (0.6%) | 2.48 | 1.85 | 1.34, 2.55 |
| Anticoagulant | |||||
| Warfarin | 281 (7.0%) | 1130 (2.8%) | 2.64 | 2.17 | 1.82, 2.59 |
| Clopidogrel | 160 (4.0%) | 532 (1.3%) | 3.16 | 2.07 | 1.66, 2.58 |
*
Adjusted for all of the variables in Table 1 (including concurrent medication use) as well as warfarin, clopidogrel and antidepressants.