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. Author manuscript; available in PMC: 2008 Jul 25.
Published in final edited form as: Heart Rhythm. 2008 Apr 9;5(6):872–879. doi: 10.1016/j.hrthm.2008.02.034

Figure 4.

Figure 4

Consequences of transgenic overexpression of IK1 on action potential characteristics and reentry wavelength and frequency. Top; Left, simulated action potential of wildtype (WT) mouse ventricular myocyte; right, simulated action potential of transgenic (TG) myocyte (grey) superimposed on WT (black). Note significant acceleration of phase-3 repolarization in TG with respect to WT. Bottom, simulation of reentry in WT and TG sheets of ventricular myocytes. Overexpression of IK1 reduces the spatial extension of the excited state (wavelength) and increases the rotation frequency (WT, 13 Hz; TG, 40 Hz). Curved arrow shows rotation direction; white dot indicates position of the core. Modified from Noujaim et al9 with permission.