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. 2008 Jul 29;6(7):e170. doi: 10.1371/journal.pbio.0060170

Figure 4. Synergistic Increases in SOD1 Aggregation Propensity and Losses of Thermodynamic Stability Are Associated with Decreased Survival of fALS Patients (Using Unweighted Data).

Figure 4

(A) An increase in aggregation propensity is associated with decreased fALS patient survival. Single point mutations found in fALS patients with corresponding reported thermodynamic stabilities in (B) were considered.

(B) A loss of SOD1 thermodynamic stability is associated with severe disease.

(C) Increase in SOD1 aggregation propensity and gain of instability synergistically decrease patient survival. The data used in these three graphs (disease durations from 580 patients with 28 different fALS-causing SOD1 mutations with reported stability values) were treated equally regardless of the number of patients using the software SigmaPlot 9.0 (Systat Software, Inc.). SPSS 15.0 also was used on this analysis, and identical results were obtained.