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. Author manuscript; available in PMC: 2009 Jun 5.
Published in final edited form as: Brain Res. 2008 Apr 8;1213:57–68. doi: 10.1016/j.brainres.2008.03.054

Figure 1. Conditioned place preference following repeated administration of cocaine.

Figure 1

Cocaine treated animals spent significantly more time in the drug-paired compartment after conditioning than their control counterparts. (a) Cocaine conditioned animals spent significantly more time in the drug-paired compartment on the CPP test day compared to the saline-conditioned animals (denoted by an asterisk) and also to the pretest day (denoted by a hash). (b) A significant shift in the preference of the cocaine treated animals was observed following conditioning compared to saline-treated animals (denoted by an asterisk). The shift in preference represents change in time spent in drug-paired compartment at the CPP test and Pre-test (sec). Data are expressed as mean ± SEM with n=29 (Veh), n= 8 (Coc 10 mg/kg), n=24 (Coc 15 mg/kg) and n=10 (Coc 20 mg/kg). Statistical significance was determined with p<0.05.