Intake of 2 mmol/L saccharin solution, water, and total fluid, and saccharin preference in B6 and 129 mice fed one of three standard cereal-based diets (Teklad 8604, Zeigler NIH-07, and Purina 5001), a “breeder” diet (Purina 5015), or two purified diets (AIN-76A and AIN-93G). Values are means ± SEM, n = 15 or 16 per strain for each diet. The following differences were significant (P < 0.01; see also Table 4): Saccharin intake: B6 > 129; standard cereal-based diets > Purina 5015 or purified diets; B6 fed standard cereal-based diets > B6 fed Purina 5015 or B6 fed purified diets: Water intake: B6 < 129; Total intake: B6 > 129; standard cereal-based diets > Purina 5015 or purified diets; B6 fed standard cereal-based diets > B6 fed Purina 5015 or B6 fed purified diets; Saccharin preference: B6 > 129; B6 fed standard cereal-based diets > B6 fed Purina 5015 or B6 fed purified diets.