Figure 3.

Photomicrographs showing AD-like pathology in the frontal association cortex of 23-year-old cynomolgus monkeys after developmental exposure to Pb. Brain tissue of control (Con) and Pb-exposed (Pb-E) 23-year-old cynomolgus monkeys was used for the analysis of immunohistochemical analysis of AD-like pathology. Sections were prepared and stained with the Aβ-specific antibody, which recognizes both Aβ1–40 and Aβ1–42 as discussed in Materials and Methods. The arrows point to Aβ-containing plaques as well as granular and intracellular staining. The staining characteristics are similar to those reported in the literature.