Table 7.

Electronegativities and Hydrophobic Parameters for various substituents.

Atom/group	Pauling Electronegativity	Hydrophobicity π [55–56]
H	2.1	0.00
F	4.0	0.14
Cl	3.0	0.71
Br	2.8	0.86
I	2.5	1.12
CH3	2.3	0.56
C(CH3)3	2.3	1.98
CF3	3.5	0.88
OCH3	2.7	−0.02
OCF3	3.7	1.04
SCF3	–	1.44
C6H5	–	1.96
SF5	–	1.23