Table 2.

Odds ratios and 95% confidence intervals for metabolic syndrome according to thirds of serum uric acid and categories of other predictors, Aerobics Center Longitudinal Study, 1977–2003

			Serum Uric Acid Thirds
	N	Cases	Lower third	Middle third		Upper third		Linear Trend p
				OR	95% CI	OR	95% CI
Men
Total^*	8,429	1,120	1.0 (Referent)	1.35	1.12, 1.61	1.60	1.34, 1.91	<0.001
Body mass index (kg/m²)^†
<25	4,256	311	1.0 (Referent)	1.45	1.07, 1.96	1.88	1.38, 2.56	<0.001
≥25	4,173	809	1.0 (Referent)	1.30	1.04, 1.63	1.58	1.28, 1.96	<0.001
Age (years)^‡
20–39	2,935	326	1.0 (Referent)	1.45	1.04, 2.03	1.54	1.10, 2.14	0.02
40–49	3,347	496	1.0 (Referent)	1.12	0.84, 1.48	1.50	1.14, 1.96	0.002
≥50	2,147	298	1.0 (Referent)	1.62	1.14, 2.28	1.80	1.28, 2.54	0.001
Metabolic syndrome risk factors at baseline^§
0	3,336	154	1.0 (Referent)	1.17	0.78, 1.76	1.53	1.01, 2.31	0.045
1	3,139	387	1.0 (Referent)	1.49	1.11, 1.99	1.78	1.34, 2.38	<0.001
2	1,954	579	1.0 (Referent)	1.28	0.96, 1.70	1.51	1.15, 1.98	0.003
Women
Total^*	1,260	44	1.0 (Referent)	0.71	0.25, 2.05	2.29	1.00, 5.27	0.02
Body mass index (kg/m²)^†
<25	1,088	25	1.0 (Referent)	0.41	0.10, 1.61	1.95	0.75, 5.05	0.10
≥25	172	19	1.0 (Referent)	2.56	0.26, 25.12	4.37	0.52, 36.53	0.12
Age (years)^‡
20–39	396	11	1.0 (Referent)	2.82	0.26, 30.19	5.12	0.57, 46.07	0.12
40–49	511	13	1.0 (Referent)	1.25	0.19, 8.29	3.14	0.61, 16.08	0.12
≥50	353	20	1.0 (Referent)	0.13	0.01, 1.16	1.16	0.36, 3.75	0.39
Metabolic syndrome risk factors at baseline^§
0	768	12	1.0 (Referent)	0.35	0.03, 4.23	3.53	0.71, 17.46	0.04
1	385	15	1.0 (Referent)	1.06	0.22, 5.19	1.64	0.40, 6.82	0.44
2	107	17	1.0 (Referent)	0.43	0.06, 3.02	1.23	0.27, 5.62	0.52

Abbreviations: OR, odds ratios; CI, confidence interval.

The ORs for the total sample of women and men are adjusted for age, examination year, body mass index, current smoking, alcohol intake, number of baseline metabolic risk factors, family history of disease, and treadmill test duration.

^†

The ORs within strata of body mass index are adjusted for age, examination year, current smoking, alcohol intake, number of baseline metabolic risk factors, family history of disease, and treadmill test duration.

^‡

The ORs within strata of age are adjusted for examination year, body mass index, current smoking, alcohol intake, number of baseline metabolic risk factors, family history of disease, and treadmill test duration.

^§

The ORs within strata of baseline metabolic syndrome risk factors are adjusted for age, examination year, body mass index, current smoking, alcohol intake, family history of disease, and treadmill test duration.