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FAK is required for high-efficiency uptake of invasin-coated beads. Internalization of invasin-coated beads by FAK knockout mouse cells (DU3, −/−) transfected with vector (Mock) or expressing FAK (FAK+) was determined by using immunoflourescence protection assay (Materials and Methods). %UPTAKE refers to percentage of beads bound to cells that were internalized. Error bars represent SE calculated for triplicate coverslips.
