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. 1998 Nov 10;95(23):13687–13691. doi: 10.1073/pnas.95.23.13687

Figure 2.

Figure 2

Effect of RA on the distribution of cathepsin B in neonatal-rat fibroblasts. (A and a) Intracellular localization of cathepsin B in nontreated fibroblasts was detected by immunofluorescence with anti-cathepsin B antibodies. The enzyme was found mainly in the perinuclear area. (B and b) Distribution of cathepsin B in RA-treated cells. After treatment with RA (1 μM for 3 h), the enzyme translocated from the perinuclear area to the cytoplasmic vesicles. (Bars for A and B = 20 μm; bars for a and b = 4 μm.)