Table 3.
Femoral static histomorphometry of 4-wk-old notch1Δ/Δ female mice and notch1loxP/loxPfemale littermate controls
| Notch1loxP/loxP | Notch1Δ/Δ | |
|---|---|---|
| Bone volume/tissue volume (%) | 7.8 ± 1.2 | 8.5 ± 0.5 |
| Trabecular separation (μm) | 174.8 ± 60.2 | 116.5 ± 3.8 |
| Trabecular number (mm−1) | 7.1 ± 1.1 | 7.9 ± 0.3 |
| Trabecular thickness (μm) | 11.1 ± 0.3 | 10.9 ± 0.7 |
| Osteoblast surface/bone surface (%) | 26.4 ± 3.0 | 22.9 ± 2.9 |
| Number of osteoblasts/bone perimeter (mm−1) | 50.2 ± 4.8 | 44.6 ± 5.7 |
| Number of osteoblasts/tissue area (mm−2) | 526.4 ± 75.1 | 555.5 ± 78.2 |
| Osteoclast surface/bone surface (%) | 12.7 ± 0.7 | 15.8 ± 1.1a |
| Number of osteoclasts/bone perimeter (mm−1) | 12.0 ± 0.7 | 14.7 ± 1.1 |
| Number of osteoclasts/tissue area (mm−2) | 130.8 ± 19.9 | 181.0 ± 10.7 |
| Eroded surface/bone surface (%) | 25.1 ± 1.1 | 31.9 ± 1.9a |
Bone histomorphometry was performed on femurs from 4-wk-old notch1Δ/Δ female mice and notch1loxP/loxPlittermate controls. Values are means ± sem; n = 5.
a
Significantly different from notch1loxP/loxPcontrols, P < 0.05.