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Tc (C) in control and CD rats before and after injection of fourth icv Ex-4 (0.3 μg), ip Ex-4 (3.0 μg/kg), or vehicle. Across-rat averaged Tc throughout the 6.5-h period after injections in control (A) and CD (B) rats. The histograms (C) represent 6.5-h averages of Tc and show significant hypothermia after both fourth icv and ip Ex-4 administration for control and CD rats. *, P < 0.05 from respective vehicle Tc.
