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. 2008 Apr 17;149(8):4059–4068. doi: 10.1210/en.2007-1743

Figure 5.

Figure 5

HR (BPM) in control and CD rats before and after injection of fourth icv Ex-4 (0.3 μg), ip Ex-4 (3.0 μg/kg), or vehicle. Across-rat averaged HR throughout the 6.5-h period after injections in control (A) and CD (B) rats is shown. The histogram (C) represents 6.5-h averages of HR and shows elevated HR in response to fourth icv Ex-4 injections. After ip Ex-4, HR was significantly elevated in control rats, compared with HRs after vehicle injection, whereas CD rats showed a nonsignificant increase in HR after ip Ex-4. *, P < 0.05 from respective vehicle heart rate.