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. 2008 May 8;149(8):3870–3880. doi: 10.1210/en.2007-1506

Figure 5.

Figure 5

A, Steady-state glucose infusion rates obtained from averaged rates of 90–120 min of 10% unlabeled glucose infusion during hyperinsulinemic-euglycemic clamp procedures in the control, DIO, and pair-fed rats. B, Glucose transport in skeletal muscle tissue evaluated by 2- deoxyglucose uptake during the last 45 min of the hyperinsulinemic-euglycemic clamp studies. C, Basal and insulin-stimulated rates of hepatic glucose production during the hyperinsulinemic euglycemic clamp procedures in awake rats. Data are means ± sem of four independent experiments, i.e. four different cohorts of control rats or DIO rats. DIO or control rats comparing the same time in the respective group: *, P < 0.05 PTP1B-ASO vs. PTP1B-sense; &, P < 0.05 pair fed vs. PTP1B-ASO; $, P < 0.05 pair-fed vs. PTP1B-sense.