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. 2008 May 8;149(8):3870–3880. doi: 10.1210/en.2007-1506

Figure 6.

Figure 6

Effect of icv PTP1B-ASO on PTPase and PTP1B activities in control and DIO rats. Total PTPase activity and PTPase activities in immunoprecipitates were assayed by incubation with the pp60c-src C-terminal phosphoregulatory peptide (TSTEPQpYQPGENL), as described in Materials and Methods. A, Total PTPase activity in hypothalamus. B, PTPase activity in PTP1B immunoprecipitates. C, PTPase activity in IR immunoprecipitate. D, PTPase activity in Jak-2 immunoprecipitates. Data are means ± sem of four independent experiments, i.e. four different cohorts of control rats or DIO rats. Control or DIO rats comparing the same time in the respective group: *, P < 0.05 PTP1B-ASO vs. PTP1B-sense; #, P < 0.05 PTP1B-sense vs. PTP1B-sense; &, P < 0.05 pair-fed vs. PTP1B-ASO; $, P < 0.05 pair-fed vs. PTP1B-sense.