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Effect of ZY in ob/ob mice. WT (♦), ob/ob (□) and leptin-injected ob/ob (▪) mice were injected with ZY or vehicle. Cellular infiltrate (A) as well as serum IL-6 (B) and PLF IL-6 (C), TNFα (D), IL-10 (E), and CXCL2 (F) were evaluated at the indicated time points. The inset in B shows IL-6 levels at 24 h after ZY. Data are mean ± sem of four to five mice per group. *, P < 0.05; **, P < 0.01; ***, P < 0.001 vs. WT. ◊◊, P < 0.01; ◊◊◊, P < 0.001 vs. ob/ob.
