Figure 4.

Effect of daily po dosing of STX64 (10 mg/kg), or STX213 (1 mg/kg) and twice weekly ip dosing of MPA (2 mg) on Ishikawa xenograft tumor growth in MF-1 OVX female nude mice. Tumor growth curves are shown in panel A. At the end of the study, tissue samples were collected for STS activity measurements in the liver (B) and tumor (C). D, Circulating plasma E2 levels were also determined. All results show mean ± sem (n = 8–9). *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with control. Vn/V0, Volume at day n/volume at d 0.