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. 2008 May 1;149(8):3909–3919. doi: 10.1210/en.2008-0286

Figure 7.

Figure 7

The hGH receptor antagonist, B2036, reduces oncogenic transformation in wild-type RL95-2 cells. A, The effect of B2036 on RL95-2 colony formation in soft agar in 10% FBS medium. Colonies were visualized under ×150 magnification. B, The effect of B2036 on RL95-2 colony formation in growth factor (GF)-containing and reduced growth factor (GFR) Matrigel. Number of colonies indicates the total number of colonies with disrupted morphology and filled lumina. Images were captured under ×400 magnification. C, Real-time PCR analysis of the effect of B2036 on the expression profile of RL95-2 cells. Results are represented as a fold change in mRNA levels in RL95-2 after B2036 treatment. **, P < 0.001.