Figure 3.

Uterine epithelial cell proliferation after combined estrogen plus progestin treatment. Ovariectomized C57BL/6 mice were treated for 3 wk with vehicle, estradiol, or estradiol plus different doses of MPA and drospirenone (DRO; n = 8 animals per treatment group). Whereas there was almost no proliferation within the uterine epithelium after vehicle treatment, estradiol (E2) led to a clear increase in BrdU incorporation. Complete inhibition of estradiol-induced uterine epithelial cell proliferation was achieved by adding increasing doses of MPA or drospirenone.