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. 2008 Apr 17;149(8):3952–3959. doi: 10.1210/en.2007-1612

Figure 5.

Figure 5

Induction of cyclin D1 and RANKL gene expression in the mammary gland by estrogen plus progestin treatment. Mammary glands of ovariectomized C57BL/6 mice that had been treated for 3 wk with either 100 ng estradiol (E2; black bar) or 100 ng estradiol plus different doses of drospirenone (white bars) or MPA (gray bars) were analyzed for the expression of cyclin D1 (A) or RANKL (B) using quantitative RT-PCR. Note that compared with drospirenone (180 mg/kg), much lower doses of MPA (0.75 mg/kg) were required to significantly potentiate estradiol-stimulated induction of both genes. *, P < 0.05; **, P < 0.01; ***, P < 0.005 (stepdown bootstrap analysis).